孙瑞娟;刘小伟;汪南平;董尔丹;

• 1:国家自然科学基金委员会医学科学部
• 2:北京大学医学部

摘要(Abstract)：

<正><正>糖脂代谢异常是重大代谢相关疾病的病理生理基础,如胰岛素抵抗、2型糖尿病、肥胖、高脂血症、脂肪肝、心血管疾病和肾脏疾病等,对其发病机制和干预措施的研究,一直是国内外医学领域关注的重大问题。代谢性核受体(Metabolic nuclear receptors)是一组与糖、脂和能量代谢密切相关的核受体的通称,主要包括过氧化物酶体增殖物激活受体

关键词(KeyWords)： 糖脂代谢;分子机制;重大疾病;成果概述

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 孙瑞娟;刘小伟;汪南平;董尔丹;

Email:

DOI: 10.16262/j.cnki.1000-8217.2014.02.010

参考文献(References)：

• [1]He H,Yang D,Ma L,et al.Telmisartan prevents weight gain and obesity through activation of peroxisome proliferator-activated receptor-delta-dependent pathways.Hypertension,2010,55(4):869-879.
• [2]Feng X,Luo Z,Ma L,et al.Angiotensin II receptor blocker telmisartan enhances running endurance of skeletal muscle through activation of the PPAR-S/AMPK pathway.J Cell Mol Med,2011,15(7):1572-1581.
• [3]Zu L,He J,Jiang H,et al.Bacterial endotoxin stimulates adipose lipolysis via toll-like receptor 4 and extracellular signal-regulated kinase pathway.J Biol Chem,2009,284(9):5915-5926.
• [4]WangP,YanZ,ZhongJ,et al.Transient receptor potential vanilloid 1 activation enhances gut glucagon-like peptide-1 secretion and improves glucose homeostasis.Diabetes,2012,61(8):2155-2165.
• [5]Luo Z,Ma L,Zhao Z,et al.TRPVl activation improves exercise endurance and energy metabolism through PGC-lo upregulation in mice.Cell Res,2012,22(3):551-564.
• [6]Xia T,Cheng Y,Zhang Q,et al.S6K1 in the central nervous system regulates energy expenditure via MC4R/CRH pathways in response to deprivation of an essential amino acid.Diabetes,2012,61(10):2461-2471.
• [7]Tsai MC,Chen L,Zhou J,et al.Shear stress induces synthetic-to-contractile phenotypic modulation in smooth muscle cells via peroxisome proliferator-activated receptor alpha/delta activations by prostacyclin released by sheared endothelial cells.Circ Res,2009,105(5):471-480.
• [8]Qin X,Wang X,Wang Y,et al.MicroRNA-19a mediates the suppressive effect of laminar flow on cyclin D1 expression in human umbilical vein endothelial cells.Proc Natl Acad Sci USA,2010,107(7):3240-3244.
• [9]Wang X,Fang X,Zhou J,et al.Shear stress activation of nuclear receptor PXR in endothelial detoxification.Proc Natl Acad Sci USA,2013,110(32):13174-13179.
• [10]Liu Y,Tian XY,Mao G,et al.Peroxisome proliferator-activated receptor-y ameliorates pulmonary arterial hypertension by inhibiting 5-hydroxytryptamine 2B receptor.Hypertension,2012,60(6):1471-1478.
• [11]Yang D,Luo Z,Ma S,et al.Activation of TRPV1 by dietary capsaicin improves endothelium-dependent vasorelaxation and prevents hypertension.Cell Metab,2010,12(2):130-141.
• [12]Lu Y,Xiong X,Wang X,et al.Yin Yang 1 promotes hepatic gluconeogenesis through upregulation of glucocorticoid receptor.Diabetes,2013,62(4):1064-1073.
• [13]Wu J,Wang C,Li S,et al.Thyroid hormone-responsive SPOT 14 homolog promotes hepatic lipogenesis,and its expression is regulated by liver X receptorαthrough a sterol regulatory element-binding protein lc-dependent mechanism in mice.Hepatology,2013,58(2):617-628.
• [14]Li J,Chi Y,Wang C,et al.Pancreatic-derived factor promotes lipogenesis in the mouse liver:role of the Forkhead box 1 signaling pathway.Hepatology,2011,53(6):1906-1916.
• [15]Lu Y,Ma Z,Zhang Z,et al.Yin Yang 1 promotes hepatic steatosis through repression of farnesoid X receptor in obese mice.Gut,2014,63(1):170-178.
• [16]Lu Y,Zhang Z,Xiong X,et al.Glucocorticoids promote hepatic cholestasis in mice by inhibiting the transcriptional activity of the farnesoid X receptor.Gastroenterology,2012,143(6):1630-1640.
• [17]Zhou Y,KongX,ZhaoP,et al.Peroxisome proliferator-activated receptor-a is renoprotective in doxorubicin-induced glomerular injury.Kidney Int,2011,79(12):1302-1311.