免疫系统细胞凋亡研究进展APOPTOSIS IN THE IMMUNE SYSTEM
范晓强,卫立辛,时玉舫
摘要(Abstract)：
综述了近年来免疫系统细胞凋亡的研究进展,特别介绍了作者对于Fas/FasL在免疫系统细胞凋亡特别是AICD中的作用和调节及共刺激与免疫细胞凋亡等方面的研究成果。
关键词(KeyWords)： 细胞凋亡;Fas;FasL;免疫细胞
基金项目(Foundation):
作者(Author): 范晓强,卫立辛,时玉舫
Email:
参考文献(References)：
- [1] Martinez-Lorenzo M J, Anel A, Gamen S et al. Activated human T cells release biosctive Fas ligand and APO2 ligand in microvesicles. J. Immunol., 1999, 163(3) : 1274-1281．
- [2] Monleon I, Martinez-Lorenzo M J, Anel A et al. CD59 cross-linking induces secretion of APO2 ligand in overactivated human T cells. Eur.J. Immunol., 2000, 30(4) : 1078-1087．
- [3] Wang R, Zhang L, Yin D et al. Protein kinase C regulates Fas (CD95/APO-1) expression. J. Immunol., 1998, 161: 2201-2207．
- [4] Shi Y, Bissonnette R P, Glynn J M et al. Inhibition of activation-induced apoptosis in T cell hybridomas by antisense oligodeoxynucleotides corresponding toc-myc. Science, 1992, 257: 1788-1790．
- [5] Wang R, Brunner T, Zhang L et al. Fungal metabolite FR901228 inhibits c-Myc and Fas ligand expression. Oncogene, 1998, 17: 1503-1508．
- [6] Yin DL, Mufson R A, Shi Y. Opioids induce the expression of the cell death receptor Fas. Nature, 1998, 397:218-220．
- [7] Yin D, Mufson R A, Wang R et al. Fas-mediated cell death promoted by opioids. Nature, 1999, 397: 218．
- [8] Radvanyi L C, Shi Y, Vaziri H et al. CD28 costimulation inhibits TCR-induced apoptosis during a primary T cell response. J. Immunol., 1996, 156: 1788-1798．
- [9] Shi Y, Radvanyi L G, Sharma A et al. CD28-mediated signaling in vivo prevents activation-induced apoptosis in the thymus and alters peripheral lymphocyte homeostasis. J. Immunol., 1995, 155: 1829-1837．
- [10] Dong Haidong, Zhu Gefeng, Koji Tamada et al. B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. Nature Medicine, 1999, 5: 1365-1368．