线粒体解耦联蛋白(uncoupling protein,UCP)与体内供热MITOCHONDRIAL UNCOUPLING PROTEINS: RESPONSIBLE FOR HEAT PRODUCTION
赵兴波,李宁,吴常信
摘要(Abstract):
综述了UCP(解耦联蛋白家族)的结构、功能及研究进展。
关键词(KeyWords): 解耦联蛋白;能量平衡;氧化磷酸化
基金项目(Foundation):
作者(Author): 赵兴波,李宁,吴常信
Email:
DOI: 10.16262/j.cnki.1000-8217.2000.05.003
参考文献(References):
- [1] Enerback S, Jacobsson A, Simpson E M et al. Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese. Nature,1997, 387:90-94.
- [2] Gura T. Uncoupling proteins provide new clue to obesity's causes. Science, 1998, 280(5368) : 1369-1370.
- [3] Ricquier D, Bouillaud F. The mitochondrial uncoupling protein: structural and genetic studies. Prog. Nucleic Acid Res. Mol. Biol., 1997,56: 83-108.
- [4] Ricquier D, Gervais C, Kader J C et al. Partial purification by guanosine-5'-diphosphate-agarose affinity chromatography of the 32,000 molecular weight polypeptide from mitochondria of brown adipose tissue. FEBS Lett., 1978, 101(1) :35-38.
- [5] Heaton G M, Wagenvoord R J, Kemp A J et al. Brown-adipose-tissue mitochondria: photoaffinity labelling of the regulatory site of energy dissipation. Eur. J. Biochem., 1978, 82(2) :515-521.
- [6] Lin C S, Klingenberg M. Isolation of the uncoupling protein from brown adipose tissue mitochondria. FEBS Lett., 1980, 113(2) :299-303.
- [7] Fleury C, Neverova M, Collins S et al. Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia. Nat. Genet., 1997, 15(3) : 269-272.
- [8] Boss O, Samec S, Paoloni-Giarobino A. Uncoupling protein-3: a new member of the mitochondrial carrer family with tissue-specific expression. FEBS Lett., 1997, 408(1) :39-42.
- [9] Solanes G, Vidal-Puig A, Grujic D et al. The human uncoupling protein-3 gene. Genomic structure, chromosomal localization, and genetic basis for short and long form transcripts. J. Biol. Chem., 1997, 272(41) : 25433-25436.
- [10] Gong Dawei, He Y, Karas et al. Uncoupling protein-3 is a mediator of thermogenesis regulated by thyroid hormone,β3-adrnergic agonists,and leptin. The Journal of Biological Chemistry, 1997, 272(39) : 24129-24132.
- [11] Mao W, Yu X X, Zhong A. UCP4, a novel brain-specific mitochondrial protein that reduces membrane potential in mammalian cells. FEBS Lett., 1999, 443(3) : 326-330.
- [12] Cassard A M, Bouillaud F, Mattei M G et al. Human uncoupling protein gene: structure, comparison with rat gene, and assignment to the long arm of chromosome 4. J. Cell Biochem., 1990, 43(3) : 255-264.
- [13] Ricguier D. Uncoupling protein-2(UCP2) : molecular and genetic studies. Int. J. Obes Relat Metab Disord, 1999, 23 Suppl 6: S38-42.
- [14] Horvath T L, Warden C H, Hajos M et al. Brain uncoupling protein 2: uncoupled neuronal mitochondria predict thermal synapses in homeostatic centers. J. Neurosci., 1999, 19(23) : 10417-10427.
- [15] Warden C. Genetics of uncoupling proteins in humans. Int. J. Obes Relat Metab Disord, 1999, 23 Suppl(6) :S46-48.
- [16] Yamada M, Hashida T, Shibusawa N et al. Genomic organization and promoter function of the mouse uncoupling protein 2(UCP2) gene.FEBS Lett., 1998, 432(1-2) :65-69.
- [17] Boss O, Giacobino J P, Muzzin P. Genomic structure of uncoupling protein-3 (UCP3) and its assignment to chromsome 11q13. Genomics, 1998, 47(3) :425-426.
- [18] Yoshitomi H, Yamazaki K, Tanaka I. Cloning of mouse uncoupling protein 3 cDNA and 5'-flanking region, and its genetic map. Gene, 1998, 215(1) :77-84.
- [19] Kaisaki P J, Woon P Y, Wallis R H et al. Location of tub and uncoupling proteins (UCP) 2 and 3 to a region of rat Chromosome 1 linked to glucose intolerance and adiposity in the Goto-Kakizaki(GK) type 2 diabetic rat. Mammalian Genome, 1998, 9:910-912.
- [20] Werner P, Neuenschwander S, Stranzinger G. Characterization of the porcine uncoupling proteins 2 and 3 (UCP2 & UCP3) and their localization to chromosome 9 p by somatic cell hybrids. Anim Genet.,1999, 30(3) :221-224.
- [21] Stone R T, Rexroad CE 3rd, Smith TP. Bovine UCP2 and UCP3 map to BTA15. Anim Cenet., 1999, 30(5) : 378-381.
- [22] Nicholls D G. The bioenergetics of brown adipose tissue mitochondria.FEBS Lett., 1976, 61(2) :103-110.
- [23] Lowell B B, S-Susulic V, Hamann A et al. Development of obesity in transgenic mice after genetic ablation of brown. Nature, 1993, 366(6457) :740-742.
- [24] Klingenberg M, Huang S G. Structure and function of the uncoupling protein from brown adipose